Isoflavones are plant-based compounds that resemble estrogen at the molecular level. In the bone tissue, isoflavones act as balanced, estrogen-like hormones which activate osteoblast cells, promoting new bone formation. Isoflavones also increase cell-signaling proteins that may inhibit the bone-absorbing activity of osteoclast cells.
Nearly all calcium within the adult skeletal system exists as a complex paired with phosphorus, called hydroxyapatite. In 1990, the USDA published a trial comparing the inexpensive calcium carbonate with calcium citrate-malate, with respect to improved bone density, in post-menopausal women. In this trial, researchers found the citrate-malate form was significantly more effective in supporting bone health than the carbonate form. OsteoPrev is formulated with calcium citrate-malate, as well as calcium hydroxyapatite, to improve calcium absorption and utilization for healthy bone density.
Magnesium plays a major role in bone formation as approximately 50% of magnesium found in the body is found in the bone. Magnesium plays numerous roles in bone health including increasing calcium absorption, acting as a cofactor for alkaline phosphatase activation, and supporting vitamin D3 conversion in the body.
Vitamin D3 (Cholecalciferol)
Vitamin D is a steroid vitamin known for its role in supporting bone health and aiding in the absorption of calcium and phosphate from the GI tract. Emerging research shows a direct correlation between bone mineral density and serum levels of 25(OH)D3, the active form of vitamin D.
Vitamin K1 (Phytonedione) and Vitamin K2 (Menaquinone)
Vitamin K is responsible for synthesizing osteocalcin, a protein involved in calcium transport and properly embedding calcium into bone tissue. Vitamin K has also been shown to decrease the activity of osteoclasts, helping to maintain bone formation and strength. Vitamin K works synergistically with vitamin D3 to improve calcium absorption and helps to bind newly absorbed calcium to the bone matrix.
Improving boron levels has been shown to support skeletal strength.
Phosphorus plays a role in bone mineralization and is a component of hydroxyapatite crystals in bone.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.